The anemia of infection. XIX. Studies on free erythrocyte coproporphyrin and protoporphyrin.

Erythrocyte coproporphyrin and protoporphyrin in ethanol-induced sideroblastic erthropoiesis.

EFFECT OF CHRONIC LEAD POISONING ON ERYTHROCYTE PROTOPORPHYRIN IN RATS

Research has shown that exposure to lead may have adverse effects at different blood lead concentrations. Lead inhibits at least two enzymes that are essential for the formation of heme, and because of the interaction of lead with these enzymes, no iron is inserted into protoporphyrin. Therefore the concentration of protoporphyrin increases in erythrocytes. The concentration of lead was mea...

Lead toxicity and heme biosynthesis.

Lead intoxication results in a disturbance of heme biosynthesis, its degree depending on the severity and duration of exposure to lead. A mild secondary, sideroblastic anemia is common; basophilic stippling may occur, especially in severe lead poisoning. Increased excretion in the urine of delta-aminolevulinic acid and coproporphyrin III may occur; porphobilinogen excretion is not usually incre...

Studies on free erythrocyte protoporphyrin, plasma iron and plasma copper in normal and anemic subjects.

T HE VARIOUS anemias have been studied and classified clinically, morphologically, therapeutically and to a less extent etiologically, but comparatively few chemical studies have been made. Investigation of the chemical changes accompanying the various types of anemia offers a new approach to their study and gives rise to the hope that as the specific defects are elucidated their correction wil...

Sideroblastic anemia with markedly increased free erythrocyte protoporphyrin without dermal photosensitivity.

A patient with idiopathic sideroblastic anemia and atypical clinical and biochemical findings is described. He had a greatly increased erythrocyte and plasma protoporphyrin, but normal urine and fecal porphyrins. The erythrocyte protoporphyrin had a fluorescence spectrum typical of free protoporphyrin, but caused no photosensitivity. Bone marrow metal chelatase activity was normal. There were n...